Brain [18F]Fluorodeoxyglucose Metabolism Assessment under Hypothyroidism and Recombinant Human Thyroid-Stimulating Hormone in Comparison with Thyroid Hormone Replacement in Patients Submitted to Total Thyroidectomy
نویسندگان
چکیده
Objective: To compare brain metabolism using [18F]fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) in total thyroidectomy patients during hypothyroidism (levothyroxine withdrawal) or under recombinant human thyroid-stimulating hormone (rhTSH) against levothyroxine intake. Methods: A of 12 were randomly divided into two groups. One group underwent the first [18F]FDG PET/CT scan after withdrawal (hypothyroidism condition) and repeated 6 months later regular intake (replacement condition). The other receiving an rhTSH injection maintained (rhTSH condition), 7 without administration. intra-group regional metabolisms compared. Results: Under condition, was significantly reduced, namely bilateral pre-frontal, temporal, anterior cingulate, primary motor cortices, insula, striatum (uncorrected voxelwise p < 0.005); No significant differences found between replacement conditions. Conclusion: administration could be a better option than for 131I treatment, serum thyroglobulin measurement, radioiodine scanning patient follow-up.
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ژورنال
عنوان ژورنال: Applied sciences
سال: 2022
ISSN: ['2076-3417']
DOI: https://doi.org/10.3390/app12199437